ea0099ep363 | Reproductive and Developmental Endocrinology | ECE2024
Allosso Francesca
, Digitale Selvaggio Lucia
, Errico Martina
, Grande Graziella
, Di Ludovico Claudia
, Navarra Raffaele
, Casale Maddalena
, Perrotta Silverio
, Pasquali Daniela
Beta thalassemia major (betaTM) is an inherited hematological disorder characterized by reduced or absent synthesis of beta-globin chains and anemia. Chronic transfusion treatment is necessary, exposing patients to iron overload comorbidities such as hypogonadism. It is due to iron accumulation in the pituitary gland and, more rarely, in testis and ovaries. HPG axis dysfunction can manifest as low estradiol or testosterone with low to normal serum LH and FSH, as commonly seen ...